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雄踞东南亚的亿万富豪——OEC集团总裁陈家栋（姜皓文 饰）继承父亲的产业，并决心开发位于太平洋爪哇海上一个已经废弃40年之久的小岛。虽然父亲极力阻拦，但是利益熏心的家栋依然发起了一个孤岛探险的比赛。他开出100万元的巨额奖金，引得彭非（陈小春 饰）、沈依琳（杨幂 饰）、小野宏（叶山豪 饰）等8名青年男女搭上了前往小岛的游艇。一切看似顺风顺水，游艇却在航行中遭遇了离奇海难，致令8个青年被迫滞留小岛。 在这座岛上，他们不仅遭到疯狂野猪的袭击，还发现了一座几成废墟的麻风病人的医院。此后不久，恐怖的事情接连发生，众人陷入一个无法退出的死亡游戏之中……。American psychologist John Holden arrives in London to participate in a symposium aiming to expose witchcraft and devil-worship as a fraud, with attention centered on a cult run by a Julian Karswell. Debarking his plane, Holden learns that the symposium leader, Henry Harrington, has suddenly died and he is now in charge. What only the audience knows is that Harrington was clearly killed by a demon, apparently summoned by Karswell to avenge his persecution. Despite both threatening and cajoling behavior by Karswell, Holden determines to proceed, though the only cult member willing to talk about his experiences is in a prison psychiatric ward, catatonic after allegedly killing yet another cult member. However, Harrington's niece, Joanna, believes, based on her uncle's notes, that Karswell may indeed have some satanic powers derived from an ancient tome in an obscure language which he has been able to translate, and attempts to warn the skeptic Holden. Karswell's mother also attempts to warn Holden off. However, the thing which begins to most get to Holden are the occasional, but mounting, sensory and mental disturbances he begins experiencing after an encounter with Karswell, and the discovery that, during this encounter, Karswell secretly slipped a slip of parchment with a curse in runic symbols on it into Holden's belongings, a parchment identical to one Harrington recorded having had passed to him in a similar manner shortly before his death... [N.B. Holden at no point stays at the Karswell estate].。